Both nymphomania and satyriasis are on the books as psychiatric disorders. Both involve seemingly insatiable needs for sex. Both are considered to be more mental than physical disorders.

I do not know where one crosses the line from a healthy sexual appetite to an excessive one to one of the disorders mentioned. I have never encountered true nymphomania or satyriasis. They could be considered forms of addiction and are frequently treated as such. That would make the answer to your question: If the need for sexual stimulation and satisfaction interferes with normal relationships, including family and work, it has become a self-destructive addicition.

Thwew were diagnoses that was quite common during periods of sexual repression such as the Dark Ages in Europe. Today, I believe it is quite rare.